Genetic variants of complement component 3 (C3) in DR4 positive and DR4 negative rheumatoid arthritis.
نویسندگان
چکیده
منابع مشابه
Genetic variants of complement component 3 (C3) in DR4 positive and DR4 negative rheumatoid arthritis.
C3 allotypes were defined in 86 Caucasoid patients with rheumatoid arthritis living in the north west of England and in 80 local, healthy controls. C3 allotype and phenotype frequencies were similar in RA (whether DR4 positive or negative) and control groups.
متن کاملAssociation of MHC and rheumatoid arthritis: HLA-DR4 and rheumatoid arthritis - studies in mice and men
Inherited susceptibility to rheumatoid arthritis (RA) is associated with the DRB1 genes encoding the human leukocyte antigen (HLA)-DR4 and HLA-DR1 molecules. Transgenic mice expressing these major histocompatibility complex (MHC) class II molecules have been developed to generate humanized models for RA. The relevance of these models for understanding RA will be discussed.
متن کاملThe association between rheumatoid arthritis and the HLA antigen DR4.
One hundred and forty-two patients with 'definite' or 'classical' rheumatoid arthritis (RA) were studied for the frequency and possible prognostic significance of HLA DR4. Of these, 122 were seropositive, while 20 were negative for rheumatoid factor (RF) in serum. The HLA antigen DR4 was significantly increased in the seropositive group (65%) as well as in the seronegative group (55%) in compar...
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Background: There are several evidences that genetic factors besides environmental triggers have important role in initiating the rheumatoid arthritis (RA). The aim of this study was to investigate the association of rheumatoid arthritis with different subtypes of HLA DR4 in Iranian patients. Methods: In an un-matched case control study, 110 rheumatoid arthritis patients (case) and 56 knee ost...
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Evidence has suggested a genetic link between the HLA-DR4 phenotype and rheumatoid arthritis (RA), particularly in its seropositive form. Such an association varies among different ethnic groups and remains controversial for seronegative patients. Data obtained for a group of 64 Chilean patients with RA (46 seropositive, 18 seronegative), as defined by the 1987 criteria of the American Rheumati...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1986
ISSN: 0003-4967
DOI: 10.1136/ard.45.4.269